Author
The University of MelbourneORCID 0000-0001-9972-9819Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Longyun Xu, Ksenija Nesic, Sally Beard…·Olga Kondrashova
This study identifies genomic mechanisms enabling BRCA1 methylation loss and promoter bypass in ovarian cancer, leading to PARP inhibitor resistance.
Ksenija Nesic, Franziska Geissler, Lijun Xu…·Matthew J. Wakefield
This study shows that DNMT1 inhibitors reduce BRCA1 promoter methylation in HGSOC, leading to BRCA1 re-expression and PARP inhibitor resistance.
Ksenija Nesic, Sally Beard, Lijun Xu…·Matthew J. Wakefield
The paper generates a homozygous BRCA1-methylated OVCAR8 cell line using CRISPR editing to study meBRCA1 stability and PARPi resistance.
Ksenija Nesic, John J. Krais, Yifan Wang…·Lyndal S. Edwards
This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.