Genomic alterations enable BRCA1 methylation loss and promoter bypass to drive resistance in high-grade serous ovarian cancer
Longyun Xu, Ksenija Nesic, Sally Beard, Jacinta L. Simmons, Xue Lu, Cassandra J. Vandenberg, Sharon M. Hoyte, Binny Jaradi, Ratana Lim, Franziska Geissler, Stacey L. Edwards, Joep Vissers, Anthony T. Papenfuss, Sean Michael Grimmond, John V. Pearson, , Olga Kondrashova
This study identifies genomic mechanisms enabling BRCA1 methylation loss and promoter bypass in ovarian cancer, leading to PARP inhibitor resistance.
bioRxiv · Jul 30, 2026 · PreprintCancer Biology