Sally Beard

This study uses scRNA-seq on amniotic fluid to create a cell atlas of healthy fetal cells, revealing gestational age-related changes in cell composition and gene expression.

This study identifies genomic mechanisms enabling BRCA1 methylation loss and promoter bypass in ovarian cancer, leading to PARP inhibitor resistance.

This study examines how amniotic fluid extracellular vesicles (AF-EVs) change with gestational age, showing shifts in EV subtypes and protein content that reflect fetal development.

This study evaluates the effects of valaciclovir, letermovir, and maribavir on first-trimester placental development and cell viability, finding no significant adverse effects on cytotrophoblast cells.

This study shows that DNMT1 inhibitors reduce BRCA1 promoter methylation in HGSOC, leading to BRCA1 re-expression and PARP inhibitor resistance.

The paper generates a homozygous BRCA1-methylated OVCAR8 cell line using CRISPR editing to study meBRCA1 stability and PARPi resistance.