Craig A. Smith

AMHY and sex determination in egg-laying mammals

This study identifies AMHY as the primary male sex determination gene in monotremes by analyzing its expression and function during sexual differentiation.

DMRT1 regulation of TOX3 modulates expansion of the gonadal steroidogenic cell lineage

The paper identifies TOX3 as a transcription factor regulated by DMRT1 that modulates steroidogenic cell lineage expansion in chicken gonads.

Fadrozole-mediated sex reversal in the embryonic chicken gonad involves a PAX2 positive undifferentiated supporting cell state

The paper shows that fadrozole induces ovotestis in female chicken embryos by creating PAX2-positive undifferentiated supporting cells, while male embryos treated with estrogen lack these cells.

Cell lineage specification during development of the anterior lateral plate mesoderm and forelimb field

This study uses single-cell transcriptomics to define cell lineage specification in the chicken embryo's anterior lateral plate mesoderm and forelimb field, identifying molecular pathways and transcription factors involved in somatic and splanchnic fate decisions.

TGIF1 is required for chicken ovarian cortical development and generation of the juxtacortical medulla

This study identifies TGIF1 as essential for chicken ovarian cortical and juxtacortical medulla development, independent of supporting cell sex lineage.