Matteo Santoro

Novel LRRK2 Kinase Inhibitors Enhance Phosphorylation and Restore Adapter Protein Binding in LRRK2 Variants

This study evaluates two series of LRRK2 inhibitors, showing that series B compounds enhance phosphorylation and restore 14-3-3 binding in LRRK2 variants, suggesting conformation-selective inhibition as a potential PD therapy.

Heterogeneous and higher-order cortical connectivity undergirds efficient, robust and reliable neural codes

The paper shows that heterogeneous and higher-order cortical connectivity allows neural networks to balance efficiency and robustness by supporting subpopulations with different roles.