Amit Sharma

This study shows that Urolithin A reduces pro-inflammatory SASP and DAMP factors by inhibiting cytosolic DNA release and cGAS-STING signaling.

This paper evaluates rodent frailty indexes and their implementation in aging studies, highlighting inconsistencies in frailty parameters and recommending standardized protocols.

This study develops an improved IPF mouse model using aged mice that better mimics the persistent disease features and senescence observed in humans.

The paper identifies LAMP1 as a cell-surface biomarker for senescent cells in aging and idiopathic pulmonary fibrosis and demonstrates its targeting using a dual antibody-drug conjugate.

This study shows γδ T cells eliminate senescent cells in aging and reduce pulmonary fibrosis by targeting senescent cells in mice and humans.

This study identifies ADAM19 as a modulator of the senescence-associated secretory phenotype (SASP) and shows that its inhibition reduces gut permeability and senescence markers in multiple species.

The paper identifies apilimod as a senolytic drug that selectively kills senescent cells by inhibiting lysosomal exocytosis, showing therapeutic benefit in a mouse model of pulmonary fibrosis.

This study identifies Musashi as a regulator of intestinal stem cell function in Drosophila, showing its role in improving survival and gut permeability after radiation exposure.