Virginia E. Sturm

The paper identifies electrophysiological activity in the anterior insular cortex associated with anxiety-related behaviors and suggests it as a potential therapeutic target.

The paper identifies a C9orf72 gene network correlated with cortical thickness in C9-FTD and implicates vulnerable cell types.

The paper investigates C9orf72 expansion carriers using radiogenomics to link peripheral blood transcriptomics with thalamic atrophy and clinical impairment, finding global transposable element de-repression and associations between C9orf72 expression and disease severity.

The paper uses scRNA-seq to analyze peripheral blood mononuclear cells from MAPT carriers and controls, finding reduced CX3CR1 and nonclassical monocytes associated with tau pathology.

This study decodes naturalistic affective behaviors from multi-day intracranial recordings using classifiers, finding high accuracy in distinguishing positive, negative, and affectless behaviors.

The paper links neuron type-specific TDP-43 pathology in the frontoinsular cortex to salience network atrophy and loss of empathy in frontotemporal dementia.

The paper identifies four time-varying functional connectivity modes in the anterior insula that exhibit both state and trait characteristics, relating to empathy and brain connectivity patterns.