Luke W. Bonham

This study examines how telomere length, epigenetic age, and mitochondrial DNA abundance interact in Alzheimer's Disease, finding that their combination affects grey-matter volume.

The paper identifies an expansion of interferon-responsive T cells in early-onset Alzheimer's disease using single-cell RNA-sequencing and ddPCR data.

The paper identifies a C9orf72 gene network correlated with cortical thickness in C9-FTD and implicates vulnerable cell types.

The paper investigates C9orf72 expansion carriers using radiogenomics to link peripheral blood transcriptomics with thalamic atrophy and clinical impairment, finding global transposable element de-repression and associations between C9orf72 expression and disease severity.

The paper uses scRNA-seq to analyze peripheral blood mononuclear cells from MAPT carriers and controls, finding reduced CX3CR1 and nonclassical monocytes associated with tau pathology.

The paper identifies rare variants in TET2 associated with early-onset Alzheimer's disease and frontotemporal dementia, highlighting both coding and non-coding variants as risk factors.

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

This study identifies genetic overlaps between frontotemporal dementia and immune-mediated diseases, finding strong enrichment with rheumatoid arthritis and moderate enrichment with other immune conditions.

This study evaluates whether a polygenic hazard score (PHS) can enhance the prediction of amyloid and tau deposition and progression to Alzheimer’s dementia when combined with biomarkers in nondemented individuals.

This paper develops and validates a polygenic hazard score to predict age-specific Alzheimer's disease risk using genetic data from multiple cohorts.