Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C.
Cilia R. Pothast, Ian Derksen, Anneloes van der Plas - van Duijn, Angela F. El Hebieshy, Wesley Huisman, Kees L. M. C. Franken, Jacques Neefjes, Jolien J. Luimstra, Marieke Griffioen, Michel G.D. Kester, Maarten H. Vermeer, Marcus Östholm, Sine Reker Hadrup, Mirjam H.M. Heemskerk, Ferenc A. Scheeren
The paper introduces a temperature-based peptide exchange method for loading different peptides into MHC-I multimers for HLA-A, B, and C alleles, enabling high-throughput T cell response analysis.
bioRxiv · Dec 23, 2024 · PreprintImmunology