Mirjam H.M. Heemskerk

This study evaluates nasal immune cell sampling methods and antigen-specific T cell detection using cryopreserved nasal swabs, finding that flocked swabs yield more cells and cryopreservation preserves functional T cells.

The paper examines how ECM composition and abundance affect tumor organization and response to Alphavirus replicon-based virotherapy using computational modeling and 3D tumor spheroid-immune co-cultures.

This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.

The study uses spectral flow cytometry to analyze immune function across populations, revealing geographical differences and TLR8's role in mRNA vaccine responses.

The paper introduces a temperature-based peptide exchange method for loading different peptides into MHC-I multimers for HLA-A, B, and C alleles, enabling high-throughput T cell response analysis.