Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions
Jason R. Klug, Xunyi Yan, Hilary A. Hoffman, Max D Engelhardt, Fumitaka Osakada, Edward M. Callaway, Xin Jin
The paper shows that corticostriatal projections to D1- and D2-SPNs are asymmetrically overlapping and that pathway-specific subcircuits control distinct behaviors.
eLife · Oct 21, 2025Peer-reviewedNeuroscience