Jing Duan

The paper investigates how intestinal inflammation affects the blood-brain barrier (BBB) and identifies transthyretin (TTR) as a key factor in BBB recovery, with reduced TTR expression linked to Alzheimer's disease.

This study shows that primate-specific Ku adaptation suppresses Alu-mediated alternative splicing, maintaining transcriptomic integrity and linking Ku function to brain development and disease.

The paper identifies specific neuronal subtypes in pediatric FCD that show significant transcriptomic alterations linked to drug-resistant epilepsy and suggests potential therapeutic targets.

This study evaluates genome sequencing in 320 Chinese children with epilepsy, finding pathogenic variants in 38.13% and demonstrating its diagnostic and therapeutic value.