Yimeng Zhu

This study shows that primate-specific Ku adaptation suppresses Alu-mediated alternative splicing, maintaining transcriptomic integrity and linking Ku function to brain development and disease.

The paper shows Ku suppresses RNA-mediated innate immune responses in human cells, enabling primate-specific Alu element expansion by reducing dsRNA-induced inflammation.

This study identifies the SAP domain of Ku70 as limiting KU lateral movement on DNA, with DNA-PKcs partially masking this function in NHEJ.

The paper identifies and characterizes the pan-NLRome of Brassica rapa, revealing diversity in NLR gene types across 17 accessions and their evolutionary and functional implications.