RNAcare integrates clinical and transcriptomic data for bulk RNA-Seq analysis, enabling hypothesis generation about gene expression-clinical symptom relationships in rheumatoid arthritis.

BMC Medical Genomics · May 21, 2025Peer-reviewedBioinformatics

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

Nick Dand, Philip E. Stuart, John Bowes, David Ellinghaus, Joanne Nititham, Jake R. Saklatvala, Maris Teder‐Laving, Laurent F. Thomas, Tanel Traks, Steffen Uebe, Gunter Assmann, David Baudry, Frank Behrens, Allison C. Billi, Matthew Arthur Brown, , James T. Elder

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

Nature Communications · Feb 28, 2025Peer-reviewedGenetic & Genomic Medicine

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

Ashley Budu‐Aggrey, Ben Michael Brumpton, Jessica Tyrrell, Sarah Watkins, Ellen Heilmann Modalsli, Carlos A. Celis-Morales, Lyn D Ferguson, Gunnhild Åberge Vie, Tom Palmer, Lars G Fritsche, Mari Løset, Jonas Bille Nielsen, Wei Zhou, Lam C. Tsoi, Andrew R. Wood, , Lavinia Paternoster

This study uses Mendelian Randomization to show that higher BMI causally increases the risk of psoriasis and eczema, with a stronger effect on psoriasis.

bioRxiv · Feb 15, 2018 · PreprintGenetics