Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity
Ashley Rider, Henry J. Grantham, Graham R. Smith…·Nick J. Reynolds
Author
King's College LondonORCID 0000-0002-1805-6278Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
7 papers
Recent·Most cited
Ashley Rider, Henry J. Grantham, Graham R. Smith…·Nick J. Reynolds
Katie Watts, Matthias Hübenthal, Silke Szymczak…·Lavinia Paternoster
This study identifies 440 genes/proteins associated with atopic dermatitis severity through multi-omics analyses and highlights four with significant cross-evidence, including CEP85, which may contribute to severity via impaired phagocytosis.
Mandi M. Wiley, Marcin Radziszewski, Bhuwan Khatri…·Christopher J. Lessard
The paper identifies five SNPs in the DDX6-CXCR5 locus associated with autoimmune diseases and shows their functional effects on gene regulation in immune and epithelial cells.
Nick Dand, Philip E. Stuart, John Bowes…·James T. Elder
This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.
Márcio Luís Acencio, Oxana Lopata, Ahmed Abdelmonem Hemedan…·Marek Ostaszewski
The paper presents the ISD map, an interactive resource modeling molecular mechanisms of psoriasis and atopic dermatitis, and identifies potential therapeutic targets through hypothesis generation.
Ariana Hernández-Cordero, Laurent F. Thomas, Alice Smail…·Francesca Capon
This paper conducts a genome-wide meta-analysis of palmoplantar pustulosis, identifying genetic associations with Th2 responses and cigarette smoking.
Jennie G Pouget, Buhm Han, Yang Wu…·Jo Knight
This paper identifies shared genetic risk factors between schizophrenia and 19 immune diseases, including three variants with pleiotropic effects and significant genetic correlations for several immune diseases.