Alexandre Martins do Nascimento

Subtype-Resolved Pain-Signaling Architectures Reveal Conserved Drug-Target Interaction Networks in DRG Nociceptors

The paper constructs and compares PPI networks of drug targets in nociceptor subtypes across mouse and human DRGs, revealing species-specific conservation and broader cellular roles of key drug targets.

Temporal regulation of TRP channels during partial sciatic nerve ligation is modulated by PLCγ in male mice

This study shows that PLCγ modulates TRP channel expression and activity during neuropathic pain development, with TAT-pQYP reversing mechanical hypersensitivity by targeting PLCγ.