Temporal regulation of TRP channels during partial sciatic nerve ligation is modulated by PLCγ in male mice
Beatriz Caroline de Moraes, Alexandre Martins do Nascimento, Elaine F. Toniolo, Ana Maria G. Dias Rodrigues, Carolina Purcell Goes, Camila Squarzoni Dale, Deborah Schechtman
This study shows that PLCγ modulates TRP channel expression and activity during neuropathic pain development, with TAT-pQYP reversing mechanical hypersensitivity by targeting PLCγ.
bioRxiv · Mar 4, 2026 · PreprintBiochemistry