Author

Kristy M. Ainslie

University of North Carolina at Chapel HillORCID 0000-0002-1820-8382Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

Eric M. BachelderiD· 4 shared Ryan N. WoodringiD· 3 shared Aaron T. Hendricksen· 2 shared Antonio LandavazoiD· 2 shared Bruce E. BloughiD· 2 shared Devika M. VarmaiD· 2 shared Elizabeth G. Graham-GuryshiD· 2 shared Erica N. PinoiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

Eric M. BachelderORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 22, 2026

Novel compounds derived from AR-12 that demonstrate host-directed clearance of intracellular Salmonella enterica Serovar Typhimurium

Elizabeth G. Graham-Gurysh, M. Shamim Hasan Zahid, Devika M. Varma…·Kristy M. Ainslie

This paper develops AR-12 analogs that show improved host-directed clearance of intracellular Salmonella Typhimurium compared to the parent compound.

DOI 10.64898/2025.12.30.696991

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivPreprintNov 4, 2025

Discovery of Host-Directed Small Molecules with Broad Anti-Leishmanial Efficacy

Elizabeth G. Graham-Gurysh, M. Shamim Hasan Zahid, Monica M. Johnson…·Kristy M. Ainslie

The paper screens 343 AR-12 analogs to identify host-directed anti-leishmanial compounds, finding four lead compounds with broad in vitro efficacy and a lysozyme-mediated mechanism.

1 citation

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BioengineeringbioRxivPreprintJul 16, 2025

Controlled Release of Poly(U) via Acetalated Dextran Microparticles for Enhanced Vaccine Adjuvant Delivery

Sophia A. Ly, Nicole Rose Lukesh, Erik S. Pena…·Kristy M. Ainslie

This study compares the efficacy of smooth and wrinkled poly(U) encapsulated in Ace-DEX microparticles for vaccine delivery, showing differential immune responses in mice.

DOI 10.1101/2025.07.16.665134

mouseproteomics

𝕏 PostBluesky

ImmunologymSpherePeer-reviewedJun 26, 2024

Multi-COBRA hemagglutinin formulated with cGAMP microparticles elicit protective immune responses against influenza viruses

Xiaojian Zhang, Hua Shi, Dylan A. Hendy…·Ted M. Ross

This study evaluates COBRA vaccines formulated with cGAMP microparticles in mice, showing enhanced antibody responses and protection against influenza viruses.

10 citations

mouseexperimental assay

𝕏 PostBluesky