This study shows that lactate production via aerobic glycolysis in myelinating Schwann cells is essential for maintaining peripheral nerve axon physiology and function.

1 citation

mousestatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 29, 2020

Long term AAV2/9-mediated silencing of PMP22 prevents CMT1A disease in rats and validates skin biomarkers as treatment outcome measure

Benoît Gautier, Hélène Hajjar, Sylvia Soares…·Nicolas Tricaud

This study shows that AAV2/9-mediated PMP22 silencing in rats prevents CMT1A disease and identifies skin biomarkers as potential outcome measures.

1 citation

ratexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 4, 2018

CMT disease 2A and demyelination decouple ATP and ROS production by axonal mitochondria

Gerben van Hameren, Graham R. Campbell, Marie Deck…·Nicolas Tricaud

The paper investigates how ATP and ROS production in axonal mitochondria differ under normal and neuropathic conditions, finding they become decoupled in disease states.

3 citations

mouseimaging

𝕏 PostBluesky