Author

Nicolas Tricaud

InsermORCID 0000-0002-1620-4046Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:imaging· 2 Research Focus:cell type annotation· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Jade Berthelot· 4 shared Benoît GautieriD· 3 shared Gerben Van HamereniD· 3 shared Marie DeckiD· 3 shared Roman ChrastiD· 3 shared Graham R. CampbelliD· 2 shared Alise Lattard· 1 shared Antoine Jouvenel· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersNeuroscience

Jade Berthelot

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Author profile →

4 papers

Recent·Most cited

Physiology and function of PNS axons rely on glycolic metabolism in myelinating Schwann cells

Marie Deck, Gerben Van Hameren, Graham Campbell, Nathalie Bernard-Marissal, Jérôme Joël Devaux, Jade Berthelot, Alise Lattard, Jean‐Jacques Médard, Benoît Gautier, Patrice Quintana, Juan Manuel Chao de la Barca, Pascal Reynier, Guy Lenaers, Roman Chrast, Nicolas Tricaud

This study shows that lactate production via aerobic glycolysis in myelinating Schwann cells is essential for maintaining peripheral nerve axon physiology and function.

bioRxiv · Apr 23, 2020 · PreprintNeuroscience

Long term AAV2/9-mediated silencing of PMP22 prevents CMT1A disease in rats and validates skin biomarkers as treatment outcome measure

Benoît Gautier, Hélène Hajjar, Sylvia Soares, Jade Berthelot, Marie Deck, Scarlette Abbou, Graham R. Campbell, Claire-Maëlle Fovet, Vlad Schütza, Antoine Jouvenel, Cyril Rivat, Michel Zérah, Virginie François Le Ravazet, Caroline Le Guiner, Patrick R. Aubourg, , Nicolas Tricaud

This study shows that AAV2/9-mediated PMP22 silencing in rats prevents CMT1A disease and identifies skin biomarkers as potential outcome measures.

bioRxiv · Jan 29, 2020 · PreprintNeuroscience

Schwann cell demyelination is triggered by a transient mitochondrial calcium release through Voltage Dependent Anion Channel 1

Nicolas Tricaud, Benoît Gautier, Gerben van Hameren, Jade Berthelot, Sergio Gonzalez, Roman Chrast

This study identifies mitochondrial calcium release through VDAC1 as a key trigger for Schwann cell demyelination via MAPK and c-Jun activation.

bioRxiv · Mar 18, 2019 · PreprintNeuroscience

CMT disease 2A and demyelination decouple ATP and ROS production by axonal mitochondria

Gerben van Hameren, Graham R. Campbell, Marie Deck, Jade Berthelot, Roman Chrast, Nicolas Tricaud

The paper investigates how ATP and ROS production in axonal mitochondria differ under normal and neuropathic conditions, finding they become decoupled in disease states.

bioRxiv · Dec 4, 2018 · PreprintNeuroscience