Author

Roman Chrast

Karolinska InstitutetORCID 0000-0003-4189-3514Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:imaging· 2 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Gerben Van HamereniD· 3 shared Jade Berthelot· 3 shared Nicolas TricaudiD· 3 shared Benoît GautieriD· 2 shared Marie DeckiD· 2 shared Alise Lattard· 1 shared Graham Campbell· 1 shared Graham R. CampbelliD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Gerben Van HamerenORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 23, 2020

Physiology and function of PNS axons rely on glycolic metabolism in myelinating Schwann cells

Marie Deck, Gerben Van Hameren, Graham Campbell…·Nicolas Tricaud

This study shows that lactate production via aerobic glycolysis in myelinating Schwann cells is essential for maintaining peripheral nerve axon physiology and function.

1 citation

mousestatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 18, 2019

Schwann cell demyelination is triggered by a transient mitochondrial calcium release through Voltage Dependent Anion Channel 1

Nicolas Tricaud, Benoît Gautier, Gerben van Hameren…·Roman Chrast

This study identifies mitochondrial calcium release through VDAC1 as a key trigger for Schwann cell demyelination via MAPK and c-Jun activation.

1 citation

mouseimaging

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 4, 2018

CMT disease 2A and demyelination decouple ATP and ROS production by axonal mitochondria

Gerben van Hameren, Graham R. Campbell, Marie Deck…·Nicolas Tricaud

The paper investigates how ATP and ROS production in axonal mitochondria differ under normal and neuropathic conditions, finding they become decoupled in disease states.

3 citations

mouseimaging

𝕏 PostBluesky