Physiology and function of PNS axons rely on glycolic metabolism in myelinating Schwann cells
Marie Deck, Gerben Van Hameren, Graham Campbell, Nathalie Bernard-Marissal, Jérôme Joël Devaux, Jade Berthelot, Alise Lattard, Jean‐Jacques Médard, Benoît Gautier, Patrice Quintana, Juan Manuel Chao de la Barca, Pascal Reynier, Guy Lenaers, Roman Chrast, Nicolas Tricaud
This study shows that lactate production via aerobic glycolysis in myelinating Schwann cells is essential for maintaining peripheral nerve axon physiology and function.
bioRxiv · Apr 23, 2020 · PreprintNeuroscience