Author

Jonathan J. Ruprecht

University of CambridgeORCID 0000-0002-1838-7245Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Albert KoulmaniD· 1 shared Andrew M. JamesiD· 1 shared Antti M. SaloiD· 1 shared Benjamin JenkinsiD· 1 shared Chak Shun YuiD· 1 shared Clarissa D. Booth· 1 shared Denis LacabanneiD· 1 shared Edmund R.S. KunjiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Albert KoulmanORCID

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1 paper

Recent·Most cited

BiochemistryNature Cell BiologyPeer-reviewedSep 15, 2026

Stereospecific GPG acylation by CLN8 drives BMP biosynthesis and its loss leads to Batten disease

Pradeep Kumar Sheokand, Denis Lacabanne, Andrew M. James…·Kasparas Petkevicius

This study identifies CLN8 as a stereospecific GPG acyltransferase critical for BMP biosynthesis, showing its loss causes Batten disease and that S,S-LPG supplementation can restore BMP and improve neurological symptoms.

5 citationstop 1%

mousezebrafish

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