Author

Denis Lacabanne

University of CambridgeORCID 0000-0002-8911-3794Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Albert KoulmaniD· 2 shared Andrew M. JamesiD· 2 shared Benjamin JenkinsiD· 2 shared Chak Shun YuiD· 2 shared Clarissa D. Booth· 2 shared Edmund R.S. KunjiiD· 2 shared Jill M. WeimeriD· 2 shared Joris van der Kleij· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Albert KoulmanORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 9, 2026

CLN6 is a glycerophosphoglycerol epimerase in bis(monoacylglycero)phosphate biosynthesis

Pradeep Kumar Sheokand, Andrew M. James, Christian Posern…·Kasparas Petkevicius

This study identifies CLN6 as a glycerophosphoglycerol epimerase essential for BMP biosynthesis, showing its deficiency disrupts lysosomal hydrolase homeostasis and can be reversed by BMP precursor supplementation.

DOI 10.64898/2026.10.07.757350

humanmouse

𝕏 PostBluesky

BiochemistryNature Cell BiologyPeer-reviewedSep 15, 2026

Stereospecific GPG acylation by CLN8 drives BMP biosynthesis and its loss leads to Batten disease

Pradeep Kumar Sheokand, Denis Lacabanne, Andrew M. James…·Kasparas Petkevicius

This study identifies CLN8 as a stereospecific GPG acyltransferase critical for BMP biosynthesis, showing its loss causes Batten disease and that S,S-LPG supplementation can restore BMP and improve neurological symptoms.

5 citationstop 1%

mousezebrafish

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