The paper identifies rare variants in CRHR2 and GRM8 as candidate susceptibility factors for eating disorders in Japanese patients through whole exome sequencing of affected sib-pairs.

medRxiv · Aug 24, 2023 · PreprintGenetic & Genomic Medicine

The alopecia areata phenotype is induced by the water avoidance stress test in cchcr1-deficient mice.

Qiaofeng Zhao, Satoshi Koyama, Nagisa Yoshihara, Atsushi Takagi, Etsuko Komiyama, Akino Wada, Akira Oka, Shigaku Ikeda

The study shows that CCHCR1-deficient mice develop alopecia areata-like hair loss after water avoidance stress, suggesting CCHCR1's role in AA pathogenesis.

Biomedicines · Jul 19, 2021Peer-reviewedGenetics

Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice

Akira Oka, Atsushi Takagi, Etsuko Komiyama, Shuhei Mano, Kazuyoshi Hosomichi, Shingo Suzuki, Nami Motosugi, Tomomi Hatanaka, Minoru Kimura, Mahoko Takahashi Ueda, So Nakagawa, Hiromi Miura, Masato Ohtsuka, Yuko Haida, Masayuki Tanaka, , Shigaku Ikeda

The paper identifies a susceptibility variant in CCHCR1 associated with alopecia areata and shows its effect in mice with patched hair loss.

bioRxiv · Apr 26, 2018 · PreprintGenomics