Hiromi Miura

This study demonstrates the SEND process in vivo using genetically engineered mouse models, showing potential for using SEND-VLPs as a gene therapy tool for delivering mRNAs to tissues.

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.

The paper identifies a susceptibility variant in CCHCR1 associated with alopecia areata and shows its effect in mice with patched hair loss.

This paper improves the GONAD method for in situ genome editing, achieving efficiency comparable to microinjection for generating germline modified animal models.

This paper introduces an efficient CRISPR protocol using long single-stranded DNA donors to generate conditional and knock-in mice with higher success rates than existing methods.

Easi-CRISPR enables efficient germline modification with long ssDNA donors, achieving up to 100% efficiency in generating knock-in and floxed alleles in mice.