Shiyang He

The paper develops a k-segment constrained HMM for LOH detection in sparse single-cell WGS data, achieving high recall and precision.

The paper maps Cas9-induced sister chromatid exchange (SCE) across genomic targets using sci-L3-Strand-seq, showing local SCE enrichment and context-dependent recombination at repetitive loci.

The paper investigates spontaneous mitotic crossovers and finds they are driven by lesions incompatible with NHEJ, instead using HR through SSB-to-DSB conversion, with error-free recombination decoupled from mutational SVs.

The paper identifies NEPRO and C18ORF21 as constitutive subunits of metazoan RNase MRP, clarifying its composition and RNA binding specificity.

The paper identifies a multivalent RBP-effector interface that enables RNA recognition accuracy and functional repurposing of effector proteins.