Eugene Valkov

The paper identifies the regulatory roles of the CCR4-NOT complex in mRNA deadenylation and decay by analyzing transcriptome-wide effects of subunit depletion.

This study investigates how PABPC1 binding and 3' UTR sequences influence deadenylation rates, revealing two mechanisms by which UTR sequences modulate deadenylation kinetics.

The paper identifies how human PUM proteins repress mRNAs by using fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex through their intrinsically disordered RD3 domain.

The paper introduces CRASP-Seq, a method to identify gene regulators of alternative splicing, and finds ZNF207 regulates LMNA splicing in progeria by interacting with U1 snRNP.

This study shows coronavirus infection limits PABPC1 activity, destabilizing short-tailed host mRNAs and enabling viral mRNAs to maintain specific poly(A)-tail lengths through synthesis and capping mechanisms.

The paper identifies an RNA sequence motif recognized by the DND1-NANOS3 complex in germ cells and shows its role in regulating mRNA expression.

This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.

The paper identifies a multivalent RBP-effector interface that enables RNA recognition accuracy and functional repurposing of effector proteins.

This study identifies DAP5 as a factor enabling re-initiation of translation on structured mRNAs with uORFs, particularly for signalling factors.

This study identifies how PUM1 and PUM2 regulate gene expression by interacting with the CCR4-NOT complex and DCP2 to repress mRNA decay.

This study identifies that Pumilio's repression domains use deadenylation and decapping factors to accelerate mRNA degradation in Drosophila.