Yi A. Yin

The paper develops a k-segment constrained HMM for LOH detection in sparse single-cell WGS data, achieving high recall and precision.

The paper maps Cas9-induced sister chromatid exchange (SCE) across genomic targets using sci-L3-Strand-seq, showing local SCE enrichment and context-dependent recombination at repetitive loci.

The paper investigates spontaneous mitotic crossovers and finds they are driven by lesions incompatible with NHEJ, instead using HR through SSB-to-DSB conversion, with error-free recombination decoupled from mutational SVs.

This paper introduces sci-L3-Strand-seq, a method for high-throughput mapping of mitotic crossover and genome instability events in single cells, and demonstrates its ability to distinguish crossover types and explore genomic features.

The paper introduces V-seq, a cost-effective method for viral genome sequencing that uses multiplexed RT primers to improve coverage and reduce costs.

The paper develops sci-LIANTI, a single-cell DNA sequencing method, to map meiotic crossovers and chromosome mis-segregation in hybrid mice, finding frequent mitotic segregation during meiosis.

The paper profiles CRISPR/Cas9-induced mutational outcomes and develops a predictive model based on sequence context to guide DSB repair outcomes.

The paper maps heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination in yeast, revealing repair mechanisms beyond the standard double-strand break model.