Wei Tao

This paper captures mouse trophectoderm-like stem cells (TELSCs) that can generate all trophoblast lineages and form trophoblast organoids, providing insights into placental development.

This study shows enalapril reduces cellular senescence and aging-related issues by enhancing antioxidative genes through phosphorylated Smad1/5/9, improving organ function and memory.

ENIGMA deconvolutes bulk RNA-seq into single-cell-type resolution using matrix completion, validated on simulated and disease-related datasets.

This study shows that alternative polyadenylation (APA) leads to longer 3' UTRs in senescent cells, affecting gene regulation through miRNA and RBP binding sites.

The paper investigates APA regulation in cellular senescence, finding genes in senescent cells preferentially use distal polyadenylation sites, associated with longer 3′ UTRs and senescence-related pathways.