Chao Zhang

This study identifies TAK-418 as a histone demethylase inhibitor that rescues schizophrenia-like phenotypes in Setd1a-deficient mice by restoring H3K4me3 levels and gene expression.

This study identifies a circuit involving mPFC Foxp2+ neurons that modulates sensory and affective pain in male mice, with therapeutic implications for chronic pain.

This study shows that reducing dysfunctional CD150high HSCs in old mice alleviates aging phenotypes and extends lifespan.

This study shows enalapril reduces cellular senescence and aging-related issues by enhancing antioxidative genes through phosphorylated Smad1/5/9, improving organ function and memory.

The paper identifies a specific NAcSh D1 subtype that regulates feeding and energy homeostasis through molecular and circuit-level mechanisms.

This study maps the molecular, cellular, and circuit organization of the prefrontal cortex and identifies a cell type involved in chronic pain pathogenesis.

iSpatial integrates spatial transcriptomic and scRNA-seq data to infer genome-wide spatial gene expression patterns with higher accuracy and reduced false signals.

ENIGMA deconvolutes bulk RNA-seq into single-cell-type resolution using matrix completion, validated on simulated and disease-related datasets.