Developmental BiologyNucleic Acids ResearchPeer-reviewed
N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression
Tong Lü, Aijun Chen, Changjin Li…·Ming Shao
This study shows that N1-methylpseudouridine modification of IVT mRNA reduces dsRNA-induced translation repression and immune responses in zebrafish embryos.