N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression
Tong Lü, Aijun Chen, Changjin Li, Kui Li, Sen Wang, Yizhuang Zhang, Boya Yang, Jiasheng Wang, Qianqian Gong, Ang Li, Xiangguo Liu, Pengcheng Ma, Bingyu Mao, De‐Li Shi, Ming Shao
This study shows that N1-methylpseudouridine modification of IVT mRNA reduces dsRNA-induced translation repression and immune responses in zebrafish embryos.
Nucleic Acids Research · Sep 10, 2025Peer-reviewedDevelopmental Biology