Jiasheng Wang

This study shows that N1-methylpseudouridine modification of IVT mRNA reduces dsRNA-induced translation repression and immune responses in zebrafish embryos.

The paper identifies Prkra dimer as a dsRNA sensor that blocks translation initiation in pluripotent cells, restricting viral replication and conserved across species.

CoRegNet constructs gene co-regulation networks from public RNA-Seq data using a beta-binomial model, outperforming existing methods and identifying non-linear and Simpson's paradox gene pairs.

The paper argues that high-throughput expression datasets are underpowered due to insufficient biological replicates and recommends at least six per condition to improve reliability.