Ming Shao

This study identifies an IFN-independent innate immune response to dsRNA in mESCs, mediated by Dhx9, p53, and Stat1, which defends against dsRNA stresses and ZIKV infection.

This study shows that N1-methylpseudouridine modification of IVT mRNA reduces dsRNA-induced translation repression and immune responses in zebrafish embryos.

The paper identifies Prkra dimer as a dsRNA sensor that blocks translation initiation in pluripotent cells, restricting viral replication and conserved across species.

The paper identifies Vrtn as a vegetally localized maternal repressor that inhibits bmp2b transcription in the marginal region, contributing to dorsoventral axis formation in zebrafish.