Ming‐Der Perng

This study reveals the helical structure of GFAP filaments in astrocytes using cryo-EM, showing coiled-coil tetramers interdigitate to form a filament tube with functional domains contributing to filament organization and disease pathogenesis.

This paper introduces a new rat model of Alexander disease that exhibits key pathological features and motor impairment, demonstrating that antisense oligonucleotide therapy can reverse GFAP pathology and white matter deficits.