Ohad Medalia

This study compares extracellular vesicles (EVs) and mechanically induced vesicles (MVs) for membrane protein structure determination, finding that MVs provide better structural representation of HER2 in native environments.

This study reveals the helical structure of GFAP filaments in astrocytes using cryo-EM, showing coiled-coil tetramers interdigitate to form a filament tube with functional domains contributing to filament organization and disease pathogenesis.

This study examines the structural changes in segmented filamentous bacteria during their transition from unicellular to filamentous forms, identifying a novel surface layer and its role in host attachment.

The paper investigates how spatial constraints and enzyme composition regulate amylosome-mediated resistant starch degradation by Ruminococcus bromii in the human colon.

This study shows that VASP and zyxin are required for the assembly of aligned actin bundles with uniform polarity at focal adhesions, while tropomyosin-decorated actin layers remain unaffected.

The paper shows that nuclear pore density regulates LAD formation during C. elegans embryogenesis, with heterochromatic LADs providing UV protection.

This study investigates the physiological impact of folded-state protein agglomerates in yeast, finding they do not disrupt proteostasis or cell fitness and show minimal effects on cellular processes.

This study identifies the molecular interactions between lamin isoforms and chromatin, revealing their role in chromatin organization and epigenetic regulation.

FilaBuster enables rapid, specific, and spatiotemporally controlled disassembly of intermediate filaments in living cells using a three-step photochemical strategy.

This study uses cryo-ET to reveal the nanoscale 3D organization of cortical actin in cellular blebs, showing short and straight actin filaments and structural parameters.