Endogenous Nitroalkene Exploits Dependence on Autophagy-Lysosome Pathway in PARPi-Resistant TNBC
Lisa Hong, Sanghoon Lee, Leonard G. Frisbie, Yaoning Zhao, John Skoko, Christopher Merkel, Tetsushi Kataura, Viktor I. Korolchuk, Lan Gardner Coffman, Adrian V. Lee, Bruce Α. Freeman, Francisco Jose Schopfer, Carola Anke Neumann
This study identifies nitro-oleic acid (OA-NO2) as a compound that re-sensitizes PARPi-resistant TNBC cells to PARPi by targeting p62 and inhibiting autophagy.
bioRxiv · Jul 4, 2025 · PreprintPharmacology & Toxicology