Bruce Α. Freeman

This study identifies nitro-oleic acid (OA-NO2) as a compound that re-sensitizes PARPi-resistant TNBC cells to PARPi by targeting p62 and inhibiting autophagy.

NO2-OA treatment improves diastolic dysfunction in HFpEF mice by enhancing mitochondrial biogenesis and oxidative phosphorylation.

This paper shows that LXA4 and its 15-oxo metabolite do not activate FPR2 receptor but instead modulate redox-sensitive pathways through electrophilic interactions.