Tetsushi Kataura

Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation

The paper identifies SQ-1 as a small molecule that activates autophagy by promoting p62 oligomerisation, improving mitochondrial clearance and cell viability in NPC1 disease models.

AMPK senses cellular levels of nicotinamide adenine dinucleotide

This study shows that AMPK senses NAD levels, with NAD binding to the gamma subunit and modulating AMPK activity, which affects metabolic pathways like mTORC1 and autophagy.

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation

This study shows that ubiquilin-2 droplets catalyze α-synuclein fibril formation in vitro and in cells, and identifies a compound that inhibits this process.

Endogenous Nitroalkene Exploits Dependence on Autophagy-Lysosome Pathway in PARPi-Resistant TNBC

This study identifies nitro-oleic acid (OA-NO2) as a compound that re-sensitizes PARPi-resistant TNBC cells to PARPi by targeting p62 and inhibiting autophagy.

Developmental mitochondrial Complex I activity determines lifespan

This study shows that developmental mitochondrial complex I dysfunction reduces lifespan and stress resistance, while adult-onset dysfunction increases lifespan and stress resistance.

Inflammation and autophagy dysfunction in metachromatic leukodystrophy: a central role for mTOR?

This study identifies inflammation and autophagy dysfunction, linked to mTOR pathway activation, as key mechanisms in metachromatic leukodystrophy using postmortem tissue analysis.

Developmental Programming of Mitochondrial Function Limits Lifespan in Short-Lived Animals

This study shows that developmental mitochondrial dysfunction limits lifespan in Drosophila, while adult dysfunction accelerates ageing, with metabolic adaptations during development being critical for survival.