The paper identifies increased GPCR pathway activity in breast cancer ovarian metastases and links it to migration and F-actin reorganization through CaSR.

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

Amal Taher Elhaw, Priscilla W. Tang, Ya-Yun Cheng, Shriya Kamlapurkar, Zaineb Javed, Sarah Al-Saad, Sierra R. White, Ahmed Emam Abdelnaby, Hannah Khan, Alex Seok Choi, Alexa L. Mattheyses, Aidan R. Cole, Yeon Soo Kim, Huda Issa Atiya, Mohamed Trebak, , Nadine Hempel

This study identifies RHOV as a detachment-sensitive Rho GTPase critical for ovarian cancer peritoneal metastasis by enhancing anoikis resistance and cytoskeletal remodeling.

Cancer Research · Apr 16, 2026Peer-reviewedCancer Biology

Endogenous Nitroalkene Exploits Dependence on Autophagy-Lysosome Pathway in PARPi-Resistant TNBC

Lisa Hong, Sanghoon Lee, Leonard G. Frisbie, Yaoning Zhao, John Skoko, Christopher Merkel, Tetsushi Kataura, Viktor I. Korolchuk, Lan Gardner Coffman, Adrian V. Lee, Bruce Α. Freeman, Francisco Jose Schopfer, Carola Anke Neumann

This study identifies nitro-oleic acid (OA-NO2) as a compound that re-sensitizes PARPi-resistant TNBC cells to PARPi by targeting p62 and inhibiting autophagy.

bioRxiv · Jul 4, 2025 · PreprintPharmacology & Toxicology

Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation

Geyon L. Garcia, Taylor J. Orellana, Grace Gorecki, Leonard G. Frisbie, Roja Baruwal, Swathi Suresh, Ester Goldfeld, Ian Beddows, I. P. MacFawn, Ananya K. Britt, Macy M. Hale, Amal Taher Elhaw, Brian Robert Isett, Nadine Hempel, Riyue Bao, , Lan Gardner Coffman

This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.

Cancer Discovery · Mar 14, 2025Peer-reviewedCancer Biology