Pharmacology & ToxicologybioRxivPreprint
Endogenous Nitroalkene Exploits Dependence on Autophagy-Lysosome Pathway in PARPi-Resistant TNBC
Lisa Hong, Sanghoon Lee, Leonard G. Frisbie…·Carola Anke Neumann
This study identifies nitro-oleic acid (OA-NO2) as a compound that re-sensitizes PARPi-resistant TNBC cells to PARPi by targeting p62 and inhibiting autophagy.
DOI 10.1101/2025.07.04.663201