Kinase activity simultaneously determines the constitutive and the orthosteric gating in α4β1/3δ GABAA receptors in hippocampal granule cells
Nils Ole Dalby, Ulrike Leurs, Christina Birkedahl Falk‐Petersen, Petra Scholze, Jacob Krall, Bente Frølund, Petrine Wellendorph
The paper shows that kinase activity affects both constitutive and agonist-induced gating of 4β1/3δ GABAA receptors in hippocampal granule cells, altering ligand efficacy and antagonist effects.
bioRxiv · May 9, 2018 · PreprintNeuroscience