Petrine Wellendorph

Development of a NanoBRET assay platform to detect intracellular target engagement in living cells for the Glycine Transporter 1 (SLC6A9)

The paper develops a NanoBRET assay to quantify intracellular GlyT1 target engagement in living cells, distinguishing intracellular from extracellular ligands and resolving structure-activity relationships.

Structural basis for selective inhibition of human GABA transporter GAT3

This study presents cryo-EM structures of human GAT3 bound to inhibitor, substrate GABA, or in substrate-free state, revealing molecular mechanisms of inhibition and substrate recognition.

Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response

The paper identifies a functional interaction between ASIC1a and MCT1 that modulates proton sensitivity and desensitization, showing its role in glioblastoma cell survival and mouse lifespan.

Allosteric factors in the calcium/calmodulin-responsive kinase II hub domain determine selectivity of GHB ligands for CaMKIIa

This study identifies allosteric factors in the CaMKII hub domain that determine GHB ligand selectivity for CaMKIIa over other isozymes.

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Inform Potential Targets for Neuroprotection

The paper identifies proteolytic events in neurons during excitotoxicity using N-terminomics, revealing calpain-mediated cleavage of synaptic proteins and potential therapeutic targets for neuroprotection.

Kinase activity simultaneously determines the constitutive and the orthosteric gating in α4β1/3δ GABAA receptors in hippocampal granule cells

The paper shows that kinase activity affects both constitutive and agonist-induced gating of 4β1/3δ GABAA receptors in hippocampal granule cells, altering ligand efficacy and antagonist effects.