Author

Denny Sakkas

Boston IVFORCID 0000-0002-9509-6791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Abigail KaijaiD· 1 shared Aidan Chen· 1 shared Alexandre ChamprouxiD· 1 shared Alice SherrardiD· 1 shared Antonio J. GiráldeziD· 1 shared Anubhav SinhaiD· 1 shared Armen SaghatelyaniD· 1 shared Arturo HernándeziD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperGenetics

Abigail KaijaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Exposure of Men to PTSD-Promoting Trauma Elevates Levels of Sperm miRNAs with Anxiety and Depression-Inducing Activities

Mitra‐Sadat Sadat‐Shirazi, Alexandre Champroux, Aidan Chen, Denny Sakkas, Tammy Maria Scott, Emily Mellen, Abigail Kaija, Larisa Ryzhova, Lucy Liaw, Arturo Hernández, Larry A. Feig

This study finds that men exposed to trauma have elevated sperm miRNAs linked to anxiety and depression in offspring, though not all trauma-exposed men show increased anxiety or depression themselves.

bioRxiv · Apr 27, 2026 · PreprintGenetics

Unified Transcriptome and Mechanics Map of the Intact Mammalian Preimplantation Embryo In Situ

Ehsan Habibi, Anubhav Sinha, Haiqian Yang, Payman Yadollahpour, Raquel Rodríguez-Aller, Yiwei Li, Lani Lee, David Wollensak, Zachary Chiang, Denny Sakkas, Edward S. Boyden, Armen Saghatelyan, Ming Guo, Aviv Regev, Fei Chen

This paper introduces UTMM, a method to simultaneously measure transcriptomes and mechanical properties in intact embryos, revealing coupling between RNA expression and intracellular compliance during early development.

bioRxiv · Feb 24, 2026 · PreprintDevelopmental Biology

Lamin A/C directs nucleosome-scale chromatin remodeling to define early lineage segregation in mammals

Alice Sherrard, Liangwen Zhong, Caroline Hoppe, Srikar Krishna Gopinath, Scott E. Youlten, Curtis W. Boswell, Stephen Cross, Fiona E Sievers, Goli Ardestani, Denny Sakkas, Liyun Miao, Zachary D. Smith, Berna Sözen, Antonio J. Giráldez

The paper investigates how Lamin A/C influences chromatin structure during early mammalian lineage segregation, showing its role in maintaining trophectoderm identity.

bioRxiv · Jan 2, 2026 · PreprintDevelopmental Biology