Hepatic Macrophage Migration Inhibitory Factor Promotes Pancreatic Cancer Liver Metastasis in NAFLD
Qian Yu, Hui Song, Liang Zhu, Xiao-ya Shi, Haizhen Wang, Ying-luo Wang, Ruining Gong, Jiu-fa Cui, Xiaonan Yang, Jigang Wang, Yu Liang, Ying Chen, Xiaowu Dong, Guotao Lu, Chang Li, , He Ren
This study shows that hepatic MIF promotes PDAC liver metastasis in NAFLD by enhancing cancer stemness and immune suppression through the MIF-CD44 axis.
bioRxiv · Jun 2, 2024 · PreprintCancer Biology