Yonglun Luo

The paper shows that STAT1 independently controls microglial neutral-lipid content without relying on lipid-handling transcriptional programs.

The paper constructs an EndoAge atlas using single-nucleus RNA-seq data from mice to characterize non-linear endothelial aging trajectories across tissues.

This study shows that thymic Treg-derived T follicular regulatory cells prevent autoimmunity by limiting GC responses during TLR7-driven inflammation.

This study constructs a multi-tissue cell atlas of pigs, identifies cell-type-specific gene regulation, and links these to complex traits and human phenotypes.

This study identifies fibro-adipogenic progenitors and macrophages as key players in elderly human skeletal muscle regeneration through spatial and single-cell transcriptomics, revealing their interplay via complement factor C3.

This study uses single-cell RNA sequencing to analyze the temporal cellular responses in the brain during HSV-1 infection, identifying distinct immune cell subpopulations and their roles in both protective and pathological processes.

This paper introduces biomimetic graphitic carbon nitride nanoparticles that enable multiscale photo-modulation of cells and tissues through light-responsive mechanisms.

This study investigates how HSP60 deficiency disrupts mitochondrial proteostasis and dysregulates cholesterol synthesis, leading to developmental abnormalities and hypomyelination.

The paper develops a method to profile extrachromosomal circular DNA (eccDNA) in plasma and finds higher eccDNA levels in lung adenocarcinoma patients compared to healthy donors.

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

The paper presents PigGTEx, a resource linking genetic variants to transcriptomic phenotypes in pigs, showing pigs' similarity to humans in gene regulation and complex traits.

The paper investigates the sex-dimorphic neuroprotective role of CD163 in a Parkinson's disease mouse model using CD163 knockout mice.

The paper integrates single-cell and single-nucleus RNA sequencing data to identify biomarkers associated with NAFLD severity and their intercellular signaling roles.

The paper identifies QSOX1 and IL1RAP as biomarkers for NAFLD severity using gene clustering and validates their plasma ratio as a non-invasive diagnostic tool.

The paper uses AlphaFold2 to cluster deaminase proteins by structure, discovers new properties, and develops improved base editors for therapeutic and agricultural use.

This study shows that SORL1 haploinsufficiency in pigs mimics early AD biomarker changes without neurodegeneration, supporting its role as a causal gene in Alzheimer's disease.

The paper annotates all human protein-coding genes with their function and spatial distribution across cell types using single-cell transcriptomics data and introduces a new classification tool.

This study identifies and characterizes over one million urinary cell free eccDNAs in healthy adults, revealing their genomic distribution, sequence features, and potential role of direct repeats in their biogenesis.

The paper introduces TRAP-seq to quantify CRISPR editing efficiency and uses it to design improved gRNAs for Cas9, ABE, and CBE with high accuracy and efficiency.

This study examines intratumor heterogeneity and evolution patterns in colorectal cancer, finding a Darwinian pattern with differences between right-sided and left-sided tumors.

The paper develops a CRISPR on-target activity prediction model called GNL using Bayesian Ridge Regression, showing improved cross-dataset and cross-species performance.

This study demonstrates CRISPR/Cas9 can generate extrachromosomal circular DNA and ring chromosomes in human cells, enabling new tools for genetic engineering and disease modeling.