Control of Ribosomal RNA Synthesis by Hematopoietic Transcription Factors
Charles Antony A, Subin S. George, Justin Blum, Patrick Somers, Chelsea L. Thorsheim, Dexter J. Wu-Corts, Yuxi Ai, Long Gao, Kaosheng Lv, Michel G. Tremblay, Tom Moss, Kai Tan, Jeremy E. Wilusz, Austen R. D. Ganley, Maxim Pimkin, Vikram R. Paralkar
The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.
Molecular Cell · Sep 15, 2022Peer-reviewedMolecular Biology