Subin S. George

Lineage-specific transcription factor CEBPA accelerates RNA Polymerase I dynamics

This study shows that the myeloid transcription factor CEBPA accelerates RNA Polymerase I dynamics at rDNA repeats by modulating promoter escape, Pol I accumulation, and DNA supercoiling resolution.

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis

The paper examines rRNA transcription and abundance in normal and leukemic hematopoiesis, finding cell-type-specific variations and functional roles in myeloid differentiation.

Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness

This study identifies PHF6 and PHIP as a chromatin complex that represses AML stemness, showing their functional relationship and the impact of their mutations.

Customized genomes for human and mouse ribosomal DNA mapping

The paper customizes genome assemblies for rDNA mapping in human and mouse by masking repetitive regions and adding reference sequences, enabling better analysis of rDNA-binding factors.

Control of Ribosomal RNA Synthesis by Hematopoietic Transcription Factors

The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.