Author

Seungkyu Lee

Boston Children's HospitalORCID 0000-0002-1929-3320Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Clifford J. WoolfiD· 2 shared Allon Moshe KleiniD· 1 shared Brian J. WaingeriD· 1 shared Bruce P. BeaniD· 1 shared Bruno BoiviniD· 1 shared Crystal Hermawan· 1 shared Dan H. Geschwind· 1 shared Devlin FrostiD· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Clifford J. WoolfORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 7, 2023

Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability

Xuan Huang, Seungkyu Lee, Riki Kawaguchi…·Clifford J. Woolf

The paper shows that reduced Kv8.1 expression in ALS motor neurons with SOD1(A4V) and C9orf72 mutations increases vulnerability to cell death by affecting metabolism and transport pathways.

DOI 10.1101/2023.05.07.539778

human

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Developmental BiologyeLifePeer-reviewedOct 9, 2017

Mouse embryonic stem cells can differentiate via multiple paths to the same state

James Briggs, Victor C. Li, Seungkyu Lee…·Marc W. Kirschner

This study compares two mouse motor neuron differentiation protocols, showing that direct programming can reach the same final state through a different intermediate state with distinct gene expression.

82 citations

mousescRNA-seq

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